• Innovation
    Promotion of technological and clinical innovation in critical care
  • Grip
    In-vitro and in-vivo research adherent to clinical practice and relevant for ICU every-day activities
  • Sharing
    International spread of ideas, innovation and research

Our philosophy

The GRIP (Group for Research in Intensive care in Pavia) is founded in 2015 by a group of intensivists working at Intensive Care Units of Policlinico S. Matteo in Pavia. We are a group of young doctors and researchers who dedicated in the last years great energy, enthusiasm and time to develop new ideas, improve technology and optimize quality of care for critical patients. Our group is characterized by strong international connections for both clinical research and technological developement. Our missions are:


  1. 1

    Intensive care units are highly technological; therefore, development of innovative instruments and optimization of existing ones can have a deep clinical impact. We have strong national and international collaborations with research and development sections of industries involved in the field and with many universities in order to push technology forward.

  2. 2

    Our aim is to promote and support a research projects gripping the real world. First, this means we support research with high clinical impact and strong everyday applicability. Second, we support researchers, offering work possibilities for young professionals.

  3. 3

    We aim to share our ideas, projects and results with scientific community; we have strong national and international research cooperation and  researcher exchange programs with multiple university centers.

Endogenous Catecholamine Release in COVID-19 Related Acute Respiratory Distress Syndrome: Link between Enhanced Sympathetic Stimulation, Cardiac Dysfunction and Outcome


The aim of this study was to measure the serum levels of catecholamines in patients admitted to intensive care unit (ICU) with COVID-19-related acute respiratory distress syndrome (ARDS) and describe their relation with clinical, inflammatory and echocardiographic parameters. Serum levels of endogenous catecholamines (norepinephrine, epinephrine and dopamine) were measured at ICU admission. We enrolled 71 patients consecutively admitted to ICU due to moderate to severe ARDS. 11 patients (15.5%) died during the admission in ICU. Serum levels of endogenous catecholamines were significantly elevated. Norepinephrine levels were higher in those with RV and LV systolic dysfunction, higher CRP, and higher IL-6. Patients with higher mortality rate were those with norepinephrine values ≥ 3124 ng/mL, CRP ≥ 17.2 mg/dL and IL-6 ≥ 102 pg/mL. Univariable analysis by Cox proportional hazards regression modelling showed that norepinephrine, IL-6 and CRP had the highest risk of acute mortality. Multivariable analysis showed that only norepinephrine and IL-6 retained in the model. Marked increase of serum catecholamine levels is present during acute phase of critically ill COVID-19 and it is associated with inflammatory and clinical parameters. Dammassa V, Voltini M, Colombo CNJ, Siano GM, Lo Coco C, Rizzo V, Corradi F, Mojoli F, Tavazzi G. J Clin Med. 2023 Feb 16;12(4):1557. doi: 10.3390/jcm12041557.
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