• Innovation
    Promotion of technological and clinical innovation in critical care
  • Grip
    In-vitro and in-vivo research adherent to clinical practice and relevant for ICU every-day activities
  • Sharing
    International spread of ideas, innovation and research

Our philosophy

The GRIP (Group for Research in Intensive care in Pavia) is founded in 2015 by a group of intensivists working at Intensive Care Units of Policlinico S. Matteo in Pavia. We are a group of young doctors and researchers who dedicated in the last years great energy, enthusiasm and time to develop new ideas, improve technology and optimize quality of care for critical patients. Our group is characterized by strong international connections for both clinical research and technological developement. Our missions are:


  1. 1

    Intensive care units are highly technological; therefore, development of innovative instruments and optimization of existing ones can have a deep clinical impact. We have strong national and international collaborations with research and development sections of industries involved in the field and with many universities in order to push technology forward.

  2. 2

    Our aim is to promote and support a research projects gripping the real world. First, this means we support research with high clinical impact and strong everyday applicability. Second, we support researchers, offering work possibilities for young professionals.

  3. 3

    We aim to share our ideas, projects and results with scientific community; we have strong national and international research cooperation and  researcher exchange programs with multiple university centers.

How to unload the left ventricle during veno-arterial extracorporeal membrane oxygenation


Eur Heart J Cardiovasc Imaging. 2023 May 31;24(6):696-698. doi: 10.1093/ehjci/jead061. Free full text here   Guido Tavazzi, Carlos L Alviar, Costanza Natalia Julia Colombo, Valentino Dammassa, Susanna Price, Christophe Vandenbriele  

The use of peripheral veno-arterial extracorporeal membrane oxygenation (VA ECMO) in patients with refractory cardiogenic shock (CS) has become increasingly common. Although bypassing and potentially supporting almost completely cardiac and respiratory function, this ECMO configuration leads to a rise in left ventricle (LV) afterload as a consequence of the increased retrograde pressure from the femoral/iliac artery to the ascending aorta. This may result in further worsening of ventricular function, from altering ventriculo/arterial coupling and from increasing left ventricular end-diastolic pressure (LVEDP) and left atrial pressure (LAP).

Recent studies have demonstrated that early LV unloading with additional percutaneous left ventricular assist devices (pLVAD) relieves ventricular distension and improves outcomes. However, the optimal unloading strategy (e.g. impella, intra-aortic balloon pump-IABP, transseptal cannulation) has not yet been defined.3,4Additionally, the criteria for the indications, timing, and mode of LV unloading (pLVAD selection), are mostly based on pathophysiology and clinical experience, rather than on high-quality evidence-based from published data. No validated indices exist or cut-off values (e.g. chamber size quantification) as patients needed VA ECMO may have a wide range of underlying cardiac morpho-functional features (e.g. CS related to acute myocardial infarction in previously normal LV or related to acute decompensated heart failure with dilated cardiomyopathy).

We aim to describe a systematic ultrasound-guided approach, integrating imaging and pathophysiological information, to select the most appropriate unloading strategy in patients with CS undergoing peripheral VA ECMO. Only percutaneous approaches will be discussed.


SMART - San Matteo Review in Trauma

By admin 30/09/2023
14:30 - 16:30
Conferences and courses

Incontro multidisciplinare per discussione di casi del Trauma Team


Aula 3 - Piano 1 DEA

FORMAZIONE OSM: Il paziente pediatrico in Rianimazione

By admin 09/10/2023
13:30 - 17:30
Conferences and courses

Responsabile Scientifico Dr. Maggio

Piano 1, Aula 2 Torre A

5.2 crediti ECM

SMART - San Matteo Review in Trauma

By admin 28/10/2023
14:30 - 16:30
Conferences and courses

Incontro multidisciplinare per discussione di casi del Trauma Team


Aula 3 - Piano 1 DEA